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  • 产品名称：CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(AA36-162)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(AA36-162)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.1 kDa. As a result of glycosylation, The protein migrates as 50-66 kDa under reducing (R) condition and 95-105 kDa under non-reducing (NR) condition on SDS-PAGE gel.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Background CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
Molecular Weight 41.1 kDa
NCBI Accession NP_033973
UniProt P09793
Restrictions For Research Use only
Format Lyophilized
Reconstitution For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
Binding Studies (Bind) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (Fc Tag) (ABIN4949168) Immobilized Mouse B7-1, Fc Tag with a linear range of 0.1-3 ng/mL.
Binding Studies (Bind) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (Fc Tag) (ABIN4949168) Immobilized Mouse B7-2, Fc Tag with a linear range of 0.4-3 ng/mL.
SDS-PAGE (SDS) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (Fc Tag) (ABIN4949168) Mouse CTLA-4, mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) and no...