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  • 产品名称：ColonyStimulatingFactor1Receptor(CSF1R)(AA20-512)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ColonyStimulatingFactor1Receptor(CSF1R)(AA20-512)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.7 kDa. The protein migrates as 95-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit the MCSF-induced proliferation of NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 4-12 pg/mL in the presence of 1 ng/mL of rhMCSF.
Background Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Molecular Weight 80.7 kDa
NCBI Accession NP_005202
UniProt P07333
Pathways RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (Fc Tag) (ABIN2180912) Human M-CSF R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
image for Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (Fc Tag) (ABIN2180912) Measured by its binding ability in a functional ELISA. Immobilized Human M-CSF, His T...