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Background
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Hypoxia-inducible factor 1, alpha subunit is also known as ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, PAS domain-containing protein 8, Class E basic helix-loop-helix protein 78 and HIF1A, is a cytoplasm and nucleus protein. HIF1A contains one basic helix-loop-helix (bHLH) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. It is expressed in most tissues with highest levels in kidney and heart. is a bHLH - PAS transcription factor found in mammalian cells growing at low oxygen concentrations. It plays an essential role in cellular and systemic responses to hypoxia. This is one of the class of hypoxia inducible factors, a family that includes Hif1a, Hif2a, and Hif3a. HIF1A activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1A plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. HIF1A interacts with the HIF1A beta / ARNT subunit. Heterodimerization of HIF1A is required for DNA binding. HIF1A interacts with COPS5. The interaction increases the transcriptional activity of HIF1A through increased stability.
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Pathways
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Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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