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  • 产品名称：PlacentaGrowthFactor(PGF)(AA19-170)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
PlacentaGrowthFactor(PGF)(AA19-170)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured in a cell proliferation assay using MDA - MB - 231 human breast cancer cells. The ED50 for this effect is typically 1 - 10 μg/mL.
Background Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Molecular Weight 20.2 kDa
NCBI Accession NP_002623
UniProt P49763
Research Area Cancer, Angiogenesis
Pathways VEGFR1 Specific Signals
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 100 mM Acetic Acid, pH 2.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Placenta Growth Factor (PGF) (AA 19-170) (Active) protein (His tag) (ABIN2181647) Human PLGF, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...