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  • 产品名称：CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(AA38-161)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CytotoxicT-Lymphocyte-AssociatedProtein4(CTLA4)(AA38-161)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
Molecular Weight 40.2 kDa
Gene ID 18, 17
UniProt Q62859
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Storage -20 °C
Supplier Images
Binding Studies (Bind) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 38-161) (Active) protein (Fc Tag) (ABIN4949207) Immobilized Mouse B7-2, His Tag with a linear range of 0.2-6 ng/mL.
SDS-PAGE (SDS) image for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 38-161) (Active) protein (Fc Tag) (ABIN4949207) Rat CTLA-4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...