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  • 产品名称：Chemokine(C-X3-CMotif)Ligand1(CX3CL1)(AA25-341)(Active)protein(Biotin,Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Chemokine(C-X3-CMotif)Ligand1(CX3CL1)(AA25-341)(Active)protein(Biotin,Histag)
详情介绍：
Brand MABSol®,PrecisionAvi
Specificity The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 35.5 kDa. The protein migrates as 50-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Grade Ultra Sensitive
Background Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.
Molecular Weight 35.5 kDa
UniProt P78423
Research Area Atherosclerosis, Chemokines, Innate Immunity, Cardiovascular
Pathways Synaptic Membrane
Comment

A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 25-341) (Active) protein (Biotin,His tag) (ABIN4949018) Biotinylated Human CX3CL1, His Tag on SDS-PAGE under reducing (R) condition. The gel ...