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  • 产品名称：C-FosInducedGrowthFactor(VascularEndothelialGrowthFactorD)(Figf)(AA93-201)(Acti

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  • 产品厂商：ACROBiosystems
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简单介绍：
C-FosInducedGrowthFactor(VascularEndothelialGrowthFactorD)(Figf)(AA93-201)(Active)protein(StrepTag,Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: The bioactivity was measured by its ability to stimulate the cell proliferation of human microvascular endothelial cells (HMVECs). The ED50 for this effect is typically 50-200 ng/mL.
Background Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in *****s. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.
Molecular Weight 13 kDa
UniProt O43915
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) (AA 93-201) (Active) protein (Strep Tag,His tag) (ABIN2181913) Human VEGF-D, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Leppänen, Jeltsch, Anisimov, Tvorogov, Aho, Kalkkinen, Toivanen, Ylä-Herttuala, Ballmer-Hofer, Alitalo: "Structural determinants of vascular endothelial growth factor-D receptor binding and specificity." in: Blood, Vol. 117, Issue 5, pp. 1507-15, 2011 (PubMed).