产品详情
查看大图

  • 产品名称：Interleukin4(IL4)(AA25-153)(Active)Protein

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Interleukin4(IL4)(AA25-153)(Active)Protein
详情介绍：
Brand ActiveMax®
Characteristics This protein carries no "tag". The protein has a calculated MW of 14.9 kDa. The protein migrates as 15 and 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50<0.2ng ml,="" corresponding="" to="" a="" specific="" activity="" of="">5X106 Unit/mg

SDS-PAGE: of reduced rhIL-4.
Background Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
Molecular Weight 14.9 kDa
UniProt P05112
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS and NaCl
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 4 (IL4) (AA 25-153) (Active) Protein (ABIN2181318) Interleukin 4 (IL4) (AA 25-153) (Active) protein
Background publications Lee, Jameson, Hogquist: "Alternative memory in the CD8 T cell lineage." in: Trends in immunology, Vol. 32, Issue 2, pp. 50-6, 2011 (PubMed).

Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: "Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites." in: Immunological reviews, Vol. 201, pp. 139-55, 2004 (PubMed).