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  • 产品名称：GlycoproteinHormones,alphaPolypeptide(CGA)(AA25-116)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
GlycoproteinHormones,alphaPolypeptide(CGA)(AA25-116)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.1 kDa. The protein migrates as 22-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Chorionic gonadotrophin subunit alpha (CGA),a member of the glycoprotein hormones subunit alpha family, is also known as glycoprotein hormones alpha chain, choriogonadotropin alpha chain, follicle-stimulating hormone alpha chain (FSH-alpha), luteinizing hormone alpha chain (LSH-alpha) and thyroid-stimulating hormone alpha chain (TSH-alpha). The hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits (CGA) of these four human glycoprotein hormones are nearly identical, however, their beta chains are unique and confer biological specificity.
Molecular Weight 12.1 kDa
UniProt P01215
Pathways Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Glycoprotein Hormones, alpha Polypeptide (CGA) (AA 25-116) (Active) protein (His tag) (ABIN2180875) Human CG alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained...
Background publications Fan, Hendrickson: "Structure of human follicle-stimulating hormone in complex with its receptor." in: Nature, Vol. 433, Issue 7023, pp. 269-77, 2005 (PubMed).

Fan, Hendrickson: "Structural biology of glycoprotein hormones and their receptors." in: Endocrine, Vol. 26, Issue 3, pp. 179-88, 2005 (PubMed).

Sairam, Li: "Human pituitary thyrotropin. The primary structure of the alpha and beta subunits." in: Canadian journal of biochemistry, Vol. 55, Issue 7, pp. 755-60, 1977 (PubMed).

Rathnam, Saxena: "Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit." in: The Journal of biological chemistry, Vol. 250, Issue 17, pp. 6735-46, 1975 (PubMed).