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  • 产品名称：LipopolysaccharideBindingProtein(LBP)(AA26-481)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
LipopolysaccharideBindingProtein(LBP)(AA26-481)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.
Molecular Weight 52.8 kDa
UniProt P18428
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Lipopolysaccharide Binding Protein (LBP) (AA 26-481) (Active) protein (His tag) (ABIN2181453) Human LBP / Lipopolysaccharide Protein ,His Tag on SDS-PAGE under reducing (R) condit...
Background publications Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, 2013 (PubMed).

Martin, Koplin, Eckert, Lowe, Ponsonby, Osborne, Gurrin, Robinson, Hill, Tang, Dharmage, Allen: "The prevalence and socio-demographic risk factors of clinical eczema in infancy: a population-based observational study." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 43, Issue 6, pp. 642-51, 2013 (PubMed).

Hubacek, Büchler, Aslanidis, Schmitz: "The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved." in: Biochemical and biophysical research communications, Vol. 236, Issue 2, pp. 427-30, 1997 (PubMed).

Schumann, Leong, Flaggs, Gray, Wright, Mathison, Tobias, Ulevitch: "Structure and function of lipopolysaccharide binding protein." in: Science (New York, N.Y.), Vol. 249, Issue 4975, pp. 1429-31, 1990 (PubMed).