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  • 产品名称：Tetraspanin26(TSPAN26)(AA113-240)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Tetraspanin26(TSPAN26)(AA113-240)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Leukocyte antigen CD37 (CD37) is also known as Tetraspanin-26 (Tspan-26) and TSPAN26,which is a member of the transmembrane 4 superfamily or tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins encoded by CD37 gene mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. CD37 may play a role in T-cell-B-cell interactions.
Molecular Weight 42.1 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tetraspanin 26 (TSPAN26) (AA 113-240) (Active) protein (Fc Tag) (ABIN2180765) Tetraspanin 26 (TSPAN26) (AA 113-240) (Active) protein (Fc Tag)
Background publications van Spriel, Puls, Sofi, Pouniotis, Hochrein, Orinska, Knobeloch, Plebanski, Wright: "A regulatory role for CD37 in T cell proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 5, pp. 2953-61, 2004 (PubMed).

Virtaneva, Angelisová, Baumruker, Horejsí, Nevanlinna, Schröder: "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes." in: Immunogenetics, Vol. 37, Issue 6, pp. 461-5, 1993 (PubMed).