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  • 产品名称：Interleukin21Receptor(IL21R)(AA20-236)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin21Receptor(IL21R)(AA20-236)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.6 kDa. As a result of glycosylation, the protein migrates as 65-80 kDa under reducing (R) condition, and 130-160 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind human IL-21 (Catalog # IL1-H4212) in a functional ELISA.
Background Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.
Molecular Weight 51.6 kDa
UniProt Q9HBE5
Pathways JAK-STAT Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 21 Receptor (IL21R) (AA 20-236) (Active) protein (Fc Tag) (ABIN2181374) Interleukin 21 Receptor (IL21R) (AA 20-236) (Active) protein (Fc Tag)
Background publications Grote, Sonnenschein, Kapopara, Hillmer, Grothusen, Salguero, Kotlarz, Schuett, Bavendiek, Schieffer: "Toll-like receptor 2/6 agonist macrophage-activating lipopeptide-2 promotes reendothelialization and inhibits neointima formation after vascular injury." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 33, Issue 9, pp. 2097-104, 2013 (PubMed).

Kotlarz, Zi?tara, Uzel, Weidemann, Braun, Diestelhorst, Krawitz, Robinson, Hecht, Pucha?ka, Gertz, Schäffer, Lawrence, Kardava, Pfeifer, Baumann, Pfister, Hanson, Schambach, Jacobs, Kreipe, Moir et al.: "Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. ..." in: The Journal of experimental medicine, Vol. 210, Issue 3, pp. 433-43, 2013 (PubMed).

Hamming, Kang, Svensson, Karlsen, Rahbek-Nielsen, Paludan, Hjorth, Bondensgaard, Hartmann: "Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R." in: The Journal of biological chemistry, Vol. 287, Issue 12, pp. 9454-60, 2012 (PubMed).