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  • 产品名称：NaturalCytotoxicityTriggeringReceptor3(NCR3)(AA19-135)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
NaturalCytotoxicityTriggeringReceptor3(NCR3)(AA19-135)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.7 kDa. The protein migrates as 20-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
Molecular Weight 13.7 kDa
UniProt O14931
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Natural Cytotoxicity Triggering Receptor 3 (NCR3) (AA 19-135) (Active) protein (His tag) (ABIN2181530) Human NKp30, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Simhadri, Reiners, Hansen, Topolar, Simhadri, Nohroudi, Kufer, Engert, Pogge von Strandmann: "Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function." in: PLoS ONE, Vol. 3, Issue 10, pp. e3377, 2008 (PubMed).

Vitale, Della Chiesa, Carlomagno, Pende, Aricò, Moretta, Moretta: "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor." in: Blood, Vol. 106, Issue 2, pp. 566-71, 2005 (PubMed).

Pende, Parolini, Pessino, Sivori, Augugliaro, Morelli, Marcenaro, Accame, Malaspina, Biassoni, Bottino, Moretta, Moretta: "Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells." in: The Journal of experimental medicine, Vol. 190, Issue 10, pp. 1505-16, 1999 (PubMed).