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  • 产品名称：Interleukin18Receptor1(IL18R1)(AA19-329)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin18Receptor1(IL18R1)(AA19-329)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 62.4 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-18 receptor 1 (IL18R1) is also known as CD218 antigen-like family member A (CD218a), IL1 receptor-related protein (IL-1Rrp or IL1R-rp), CDw218a, IL18Ra, IL1RRP, which belongs to the interleukin-1 receptor family. IL18R1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL18R1 is receptor for interleukin 18 (IL-18). IL18R1 binds to the agonist leads to the activation of NF-kappa-B, but does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.
Molecular Weight 62.4 kDa
UniProt Q13478
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 18 Receptor 1 (IL18R1) (AA 19-329) (Active) protein (Fc Tag) (ABIN2181354) Interleukin 18 Receptor 1 (IL18R1) (AA 19-329) (Active) protein (Fc Tag)
Background publications Torigoe, Ushio, Okura, Kobayashi, Taniai, Kunikata, Murakami, Sanou, Kojima, Fujii, Ohta, Ikeda, Ikegami, Kurimoto: "Purification and characterization of the human interleukin-18 receptor." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25737-42, 1997 (PubMed).

Parnet, Garka, Bonnert, Dower, Sims: "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 3967-70, 1996 (PubMed).