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  • 产品名称：ProteinCReceptor,Endothelial(PROCR)(AA18-209)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ProteinCReceptor,Endothelial(PROCR)(AA18-209)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 33-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
Molecular Weight 22.8 kDa
UniProt Q9UNN8
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Protein C Receptor, Endothelial (PROCR) (AA 18-209) (Active) protein (His tag) (ABIN2181663) Human PROCR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications McInnes, Pidcock, Oganesyan, Cheesman, Powell, Thomson: "Optical detection of spin polarization in single-molecule magnets [Mn(12)O(12)(O(2)CR)(16)(H(2)O)(4)]." in: Journal of the American Chemical Society, Vol. 124, Issue 31, pp. 9219-28, 2002 (PubMed).

Oganesyan, Oganesyan, Terzyan, Qu, Dauter, Esmon, Esmon: "The crystal structure of the endothelial protein C receptor and a bound phospholipid." in: The Journal of biological chemistry, Vol. 277, Issue 28, pp. 24851-4, 2002 (PubMed).

Fukudome, Esmon: "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor." in: The Journal of biological chemistry, Vol. 269, Issue 42, pp. 26486-91, 1994 (PubMed).