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  • 产品名称：NaturalCytotoxicityTriggeringReceptor1(NCR1)(AA22-254)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
NaturalCytotoxicityTriggeringReceptor1(NCR1)(AA22-254)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53 kDa. The protein migrates as 53-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Molecular Weight 53 kDa
UniProt O76036
Pathways Regulation of Leukocyte Mediated Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 22-254) (Active) protein (Fc Tag) (ABIN2181529) Human NKp46, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Pessino, Sivori, Bottino, Malaspina, Morelli, Moretta, Biassoni, Moretta: "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity." in: The Journal of experimental medicine, Vol. 188, Issue 5, pp. 953-60, 1998 (PubMed).