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  • 产品名称：InterferongammaReceptor1(IFNGR1)(AA18-245)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
InterferongammaReceptor1(IFNGR1)(AA18-245)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.4 kDa. The protein migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interferon gamma receptor 1 (IFNGR1) is also known as CD antigen CD119, which belongs to the type II cytokine receptor family. IFNGR1 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. IFNGR1 / CD119 is receptor for interferon gamma. Two receptors bind one interferon gamma (IFNG) dimer.
Molecular Weight 52.4 kDa
UniProt P15260
Pathways Interferon-gamma Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) (Active) protein (Fc Tag) (ABIN2181259) Human IFN-gamma R1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stai...
Background publications Tauszig, Jouanguy, Hoffmann, Imler: "Toll-related receptors and the control of antimicrobial peptide expression in Drosophila." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10520-5, 2000 (PubMed).

Jouanguy, Dupuis, Pallier, Döffinger, Fondanèche, Fieschi, Lamhamedi-Cherradi, Altare, Emile, Lutz, Bordigoni, Cokugras, Akcakaya, Landman-Parker, Donnadieu, Camcioglu, Casanova: "In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma." in: The Journal of clinical investigation, Vol. 105, Issue 10, pp. 1429-36, 2000 (PubMed).

Walter, Windsor, Nagabhushan, Lundell, Lunn, Zauodny, Narula: "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor." in: Nature, Vol. 376, Issue 6537, pp. 230-5, 1995 (PubMed).

Aguet, Dembi?, Merlin: "Molecular cloning and expression of the human interferon-gamma receptor." in: Cell, Vol. 55, Issue 2, pp. 273-80, 1988 (PubMed).