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  • 产品名称：Lymphocyte-ActivationGene3(LAG3)(AA23-450)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Lymphocyte-ActivationGene3(LAG3)(AA23-450)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus, and has a calculated MW of 47 kDa. The predicted N-terminus is Leu 23. The reducing (R) protein migrates as 55-60 kDa in SDS-PAGE due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
Molecular Weight 47 kDa
UniProt P18627
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag) (ABIN2181447) Human LAG-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Binding Studies (Bind) image for Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag) (ABIN2181447) Immobilized Human LAG-3, His Tag can bind anti-LAG-3 mAb with a linear range of 0.5-...
Background publications Baixeras, Huard, Miossec, Jitsukawa, Martin, Hercend, Auffray, Triebel, Piatier-Tonneau: "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens." in: The Journal of experimental medicine, Vol. 176, Issue 2, pp. 327-37, 1992 (PubMed).

Triebel, Jitsukawa, Baixeras, Roman-Roman, Genevee, Viegas-Pequignot, Hercend: "LAG-3, a novel lymphocyte activation gene closely related to CD4." in: The Journal of experimental medicine, Vol. 171, Issue 5, pp. 1393-405, 1990 (PubMed).