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  • 产品名称：Kallikrein-RelatedPeptidase13(KLK13)(AA18-262)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Kallikrein-RelatedPeptidase13(KLK13)(AA18-262)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC ( R&D Systems, Catalog # ES011). The specific activity is > 150 pmoles / min / μg.

SDS-PAGE: due to glycosylation.
Background Kallikrein-13 (KLK13) is also known as Kallikrein-like protein 4 (KLK-L4), is a secreted protein, belongs to the peptidase S1 family and Kallikrein subfamily. KLK-13 contains one peptidase S1 domain. KLK13 is mainly expressed in prostate, breast, testis and salivary gland. KLK13 may be involved in the pathogenesis and / or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.
Molecular Weight 28 kDa
UniProt Q9UKR3
Pathways Complement System
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 20 mM MES, 150 mM NaCl, pH 6.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Kallikrein-Related Peptidase 13 (KLK13) (AA 18-262) (Active) protein (His tag) (ABIN2181432) Human Kallikrein 13, His Tag on SDS-PAGE under reducing (R) condition. The gel was st...
Background publications Petraki, Gregorakis, Papanastasiou, Karavana, Luo, Diamandis: "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues." in: Prostate cancer and prostatic diseases, Vol. 6, Issue 3, pp. 223-7, 2003 (PubMed).

Yousef, Chang, Diamandis: "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11891-8, 2000 (PubMed).