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  • 产品名称：HepatitisAVirusCellularReceptor2(HAVCR2)(AA22-200)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
HepatitisAVirusCellularReceptor2(HAVCR2)(AA22-200)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.8 kDa. The protein migrates as 44-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Molecular Weight 21.8 kDa
UniProt Q8TDQ0
Pathways Regulation of Lipid Metabolism by PPARalpha
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) (AA 22-200) (Active) protein (His tag) (ABIN2181817) Human TIM-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Binding Studies (Bind) image for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) (AA 22-200) (Active) protein (His tag) (ABIN2181817) Immobilized Human TIM-3, His Tag can bind anti-TIM3 mAb with a linear range of 0.2-3...
Background publications Anderson, Anderson: "TIM-3 in autoimmunity." in: Current opinion in immunology, Vol. 18, Issue 6, pp. 665-9, 2006 (PubMed).

Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1093-101, 2003 (PubMed).

Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: "Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance." in: Nature immunology, Vol. 4, Issue 11, pp. 1102-10, 2003 (PubMed).

Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease." in: Nature, Vol. 415, Issue 6871, pp. 536-41, 2002 (PubMed).

Munder, Bettelli, Monney, Slavik, Nicholson, Kuchroo: "Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand." in: The Journal of experimental medicine, Vol. 196, Issue 9, pp. 1151-62, 2002 (PubMed).