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  • 产品名称：CD93Molecule(CD93)(AA22-580)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD93Molecule(CD93)(AA22-580)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to induce TNF-alpha secretion by THP-1 human acute monocytic leukemia cells. The ED50 for this effect is typically 3-25 μg/mL.

SDS-PAGE: due to glycosylation.
Background CD antigen CD93 is also known as Complement component C1q receptor (C1QR1). which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.
Molecular Weight 59 kDa
UniProt Q9NPY3
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD93 Molecule (CD93) (AA 22-580) (Active) protein (His tag) (ABIN2180858) Human C1q R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Kittlesen, Chianese-Bullock, Yao, Braciale, Hahn: "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation." in: The Journal of clinical investigation, Vol. 106, Issue 10, pp. 1239-49, 2000 (PubMed).

Nepomuceno, Ruiz, Park, Tenner: "C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 6, pp. 3583-9, 1999 (PubMed).

Ghebrehiwet, Lu, Zhang, Keilbaugh, Leigh, Eggleton, Reid, Peerschke: "Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1429-36, 1997 (PubMed).