产品详情
查看大图

  • 产品名称：CD22Molecule(CD22)(AA176-687)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
CD22Molecule(CD22)(AA176-687)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 57.8 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Molecular Weight 57.8 kDa
UniProt P20273
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD22 Molecule (CD22) (AA 176-687) (Active) protein (His tag) (ABIN2180726) Human Siglec-2 (176-687), His Tag on SDS-PAGE under reducing (R) condition. The gel w...
Background publications Hatta, Tsuchiya, Matsushita, Shiota, Hagiwara, Tokunaga: "Identification of the gene variations in human CD22." in: Immunogenetics, Vol. 49, Issue 4, pp. 280-6, 1999 (PubMed).

Tuscano, Engel, Tedder, Agarwal, Kehrl: "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22." in: European journal of immunology, Vol. 26, Issue 6, pp. 1246-52, 1996 (PubMed).

Doody, Justement, Delibrias, Matthews, Lin, Thomas, Fearon: "A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP." in: Science (New York, N.Y.), Vol. 269, Issue 5221, pp. 242-4, 1995 (PubMed).