TumorNecrosisFactorReceptorSuperfamily,Member4(TNFRSF4)(AA29-216)(Active)protei 抗体网

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产品名称：TumorNecrosisFactorReceptorSuperfamily,Member4(TNFRSF4)(AA29-216)(Active)protei
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产品厂商：ACROBiosystems
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简单介绍：

TumorNecrosisFactorReceptorSuperfamily,Member4(TNFRSF4)(AA29-216)(Active)protein(Histag)

详情介绍：

Product details
Product details
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity	>90 % as determined by SDS-PAGE.
Sterility	0.22 μm filtered
Endotoxin Level	Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment	Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF4 / OX40 / CD134 at 2 μg/mL (100 μL/well) can bind human TNFSF4 Fc Chimera, The EC50 of human TNFSF4 Fc Chimera is 30 ng/mL. SDS-PAGE: due to glycosylation.

Target details
Target details
Background	Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4 / OX40L / GP34 and can interacts with TRAF2, TRAF3 and TRAF5.
Molecular Weight	22 kDa
NCBI Accession	NP_003318
Pathways	Production of Molecular Mediator of Immune Response

Application Details
Application Details
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer	PBS, pH 7.4
Handling Advice	Avoid repeated freeze-thaw cycles.
Storage	-20 °C
Storage Comment	No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Images
Images
Supplier Images	Human OX40, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove... Immobilized Human OX40, His Tag (Cat# OX0-H5224) at 2 μg/mL (100 μl/well) can bind Hu... Images for product: Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His tag) Human OX40, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. Immobilized Human OX40, His Tag (Cat# OX0-H5224) at 2 μg/mL (100 μl/well) can bind Human OX40 Ligand, Fc Tag (Cat# OXL-H526x ) with a linear range of 2-15 ng/mL.

References
References
Background publications	Arch, Thompson: "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 558-65, 1998 (PubMed). Kawamata, Hori, Imura, Takaori-Kondo, Uchiyama: "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation." in: The Journal of biological chemistry, Vol. 273, Issue 10, pp. 5808-14, 1998 (PubMed).