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  • 产品名称：LY6/PLAURDomainContaining3(LYPD3)(AA31-286)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
LY6/PLAURDomainContaining3(LYPD3)(AA31-286)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.7 kDa. The protein migrates as 45-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Ly6/PLAUR domain-containing protein 3 (LYPD3) is also known as MIG-C4 ,C4.4A, GPI-anchored metastasis-associated protein C4.4A homolog and Matrigel-induced gene C4 protein,which is a cell membrane protein containing two UPAR/Ly6 domains. LYPD3 is expressed in placenta, skin and urothelium. LYPD3 is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. LYPD3 play a role in supporting cell migration and it is not only probably involved in urothelial cell-matrix interactions, but also in tumor progression.
Molecular Weight 28.7 kDa
UniProt O95274
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for LY6/PLAUR Domain Containing 3 (LYPD3) (AA 31-286) (Active) protein (His tag) (ABIN2181492) Human LYPD3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Oshiro, Yamamoto, Takahashi, Ohtsuka, Wu, Nishimura, Takemasa, Mizushima, Ikeda, Sekimoto, Matsuura, Doki, Mori: "C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer." in: Cancer science, Vol. 103, Issue 6, pp. 1155-64, 2012 (PubMed).

Fletcher, Patel, Tyson, Adam, Schenker, Loader, Daviet, Legrain, Parekh, Harris, Terrett: "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan." in: British journal of cancer, Vol. 88, Issue 4, pp. 579-85, 2003 (PubMed).