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  • 产品名称：SialicAcidBindingIg-LikeLectin6(SIGLEC6)(AA16-320)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
SialicAcidBindingIg-LikeLectin6(SIGLEC6)(AA16-320)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.3 kDa. As a result of glycosylation, the protein migrates as 80-90 kDa under reducing (R) condition, and 160-180 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind biotinylated Neu5Ac alpha 2-6GalNAc alpha (sialyl-Tn).
Background Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Molecular Weight 60.3 kDa
UniProt O43699
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6) (AA 16-320) (Active) protein (Fc Tag) (ABIN2181763) Human Siglec-6, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions...
Background publications Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: "OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22729-38, 1999 (PubMed).

Takei, Sasaki, Fujiwara, Takahashi, Muto, Nakamura: "Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta." in: Cytogenetics and cell genetics, Vol. 78, Issue 3-4, pp. 295-300, 1998 (PubMed).