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  • 产品名称：BoneMorphogeneticProteinReceptor,TypeIB(BMPR1B)(AA14-126)(Active)protein(Histag

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  • 产品厂商：ACROBiosystems
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简单介绍：
BoneMorphogeneticProteinReceptor,TypeIB(BMPR1B)(AA14-126)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.5 kDa. The protein migrates as 20 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Purity >96 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit rhBMP4 induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.02-0.15 μg/mL in the presence of 30 ng/mL of rhBMP4.

SDS-PAGE: of reduced rhALK6.
Background The bone morphogenetic protein receptor, type IB is also known as BMPR1B or ALK6 is a protein which in humans is encoded by the BMPR1B gene. Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors activin-like kinase (ALK) 3 and ALK6 share a high degree of homology, yet possess distinct signaling roles. Decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro, and BMPR-IB mediates an inhibitory effect on breast cancer cells. Researchers found that BMP-2-induced apoptosis was mediated by BMP-RIB in osteoblasts and occurred independently of BMP-2-induced osteoblast differentiation.
Molecular Weight 13.5 kDa
UniProt O00238
Restrictions For Research Use only
Format Lyophilized
Reconstitution For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 14-126) (Active) protein (His tag) (ABIN2180585) Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 14-126) (Active) protein (His tag)
Background publications Lee, Kirkbride, Sheu, Blobe: "The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors." in: Molecular biology of the cell, Vol. 20, Issue 20, pp. 4362-70, 2009 (PubMed).