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  • 产品名称：FrizzledFamilyReceptor4(FZD4)(AA37-180)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FrizzledFamilyReceptor4(FZD4)(AA37-180)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
Molecular Weight 42.9 kDa
UniProt Q9ULV1
Pathways WNT Signaling, Hormone Transport, Sensory Perception of Sound
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Frizzled Family Receptor 4 (FZD4) (AA 37-180) (Active) protein (Fc Tag) (ABIN2181126) Frizzled Family Receptor 4 (FZD4) (AA 37-180) (Active) protein (Fc Tag)
Background publications Nallathambi, Shukla, Rajendran, Namperumalsamy, Muthulakshmi, Sundaresan: "Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy." in: Molecular vision, Vol. 12, pp. 1086-92, 2006 (PubMed).

Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).