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  • 产品名称：FibroblastGrowthFactorReceptor-Like1(FGFRL1)(AA25-378)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FibroblastGrowthFactorReceptor-Like1(FGFRL1)(AA25-378)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 65.5 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human FGFRL1 /FGFR5 Protein, C-Fc Tag (Catalog # FG1-H5250) at 5 μg/mL (100 μL/well) can bind Biotinylated Human bFGF Protein (Catalog # BFF-H8117). The EC50 is typically 2.31 μg/mL.

SDS-PAGE: due to glycosylation.
Background Fibroblast growth factor receptor 5 (FGFR-5) is also known as Fibroblast growth factor receptor-like 1 (FGFRL1), FGF homologous factor receptor (FHFR), is a single-pass type I membrane protein. FGFRL1 / FGFR5 contains three Ig-like C2-type (immunoglobulin-like) domains. FGFR-5 is expressed preferentially in cartilaginous tissues and pancreas and highly expressed in the liver, kidney, heart, brain and skeletal muscle. FGF RL1 / FGFR5 has a negative effect on cell proliferation. FGFR5 interacts with FGF2 with a low affinity.
Molecular Weight 65.5 kDa
UniProt Q8N441
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 25-378) (Active) protein (Fc Tag) (ABIN2181101) Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 25-378) (Active) protein (Fc Tag)
Background publications Li, Zhuang, Reinhard, Trueb: "The lipoma preferred partner LPP interacts with alpha-actinin." in: Journal of cell science, Vol. 116, Issue Pt 7, pp. 1359-66, 2003 (PubMed).

Trueb, Zhuang, Taeschler, Wiedemann: "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 33857-65, 2003 (PubMed).

Sleeman, Fraser, McDonald, Yuan, White, Grandison, Kumble, Watson, Murison: "Identification of a new fibroblast growth factor receptor, FGFR5." in: Gene, Vol. 271, Issue 2, pp. 171-82, 2001 (PubMed).

Wiedemann, Trueb: "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors." in: Genomics, Vol. 69, Issue 2, pp. 275-9, 2001 (PubMed).