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  • 产品名称：S100CalciumBindingProteinA10(S100A10)(AA1-97)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
S100CalciumBindingProteinA10(S100A10)(AA1-97)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12 kDa. The protein migrates as 12 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background S100 calcium-binding protein A10 (S100A10), a member of the S100 family of proteins containing two EF-hand calcium-binding motifs, is also known as protein S100-A10, calpactin I light chain, cellular ligand of annexin II, p10 protein and p11, which can be found as a free monomer, a homodimer, or a heterotetramer composed of a p11 dimer complex with two molecules of annexin II. S100A10 is an integral part of cellular structural scaffolding that interacts with plasma membrane proteins through its association with annexin II. S100A10 also works together with cytosolic and peripheral membrane-associated proteins such as AHNAK in the development of the intracellular membrane. Furthermore,S100A10 has been implicated in the transportation of proteins involved in mood regulation, nociception, and cell polarization. Complexed with the annexin II, S100A10 binds receptor and channel proteins and guides them to the cell surface, resulting in increased membrane localization and consequent magnified functional expression of these proteins.
Molecular Weight 12 kDa
UniProt P60903
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for S100 Calcium Binding Protein A10 (S100A10) (AA 1-97) (Active) protein (His tag) (ABIN2181711) Human S100A10, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: "Lysine acetylation targets protein complexes and co-regulates major cellular functions." in: Science (New York, N.Y.), Vol. 325, Issue 5942, pp. 834-40, 2009 (PubMed).

Réty, Sopkova, Renouard, Osterloh, Gerke, Tabaries, Russo-Marie, Lewit-Bentley: "The crystal structure of a complex of p11 with the annexin II N-terminal peptide." in: Nature structural biology, Vol. 6, Issue 1, pp. 89-95, 1999 (PubMed).