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  • 产品名称：ScavengerReceptorClassB,Member2(SCARB2)(AA27-432)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ScavengerReceptorClassB,Member2(SCARB2)(AA27-432)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.5 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 μg/mL (100 μL/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 μg/mL.
Background Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
Molecular Weight 72.5 kDa
UniProt Q14108
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Scavenger Receptor Class B, Member 2 (SCARB2) (AA 27-432) (Active) protein (Fc Tag) (ABIN2181727) Human SCARB2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Chen, Jiang, Sun, Han, Wang, Ye, Wang, Zou: "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." in: Journal of proteome research, Vol. 8, Issue 2, pp. 651-61, 2009 (PubMed).

Reczek, Schwake, Schröder, Hughes, Blanz, Jin, Brondyk, Van Patten, Edmunds, Saftig: "LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase." in: Cell, Vol. 131, Issue 4, pp. 770-83, 2007 (PubMed).

Schröder, Wrocklage, Pan, Jäger, Kösters, Schäfer, Elsässer, Mann, Hasilik: "Integral and associated lysosomal membrane proteins." in: Traffic (Copenhagen, Denmark), Vol. 8, Issue 12, pp. 1676-86, 2007 (PubMed).