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  • 产品名称：Signal-RegulatoryProteingamma(SIRPG)(AA29-364)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Signal-RegulatoryProteingamma(SIRPG)(AA29-364)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 68-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Signal-regulatory protein gamma (SIRPG or SIRP-gamma) is also known as CD172 antigen-like family member B (CD172g), Signal-regulatory protein beta-2 (SIRPB2), is a single-pass type I membrane protein. SIRPG is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG interacts with CD47. On binding with CD47, CD172g mediates cell-cell adhesion.
Molecular Weight 63.7 kDa
UniProt Q9P1W8
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Signal-Regulatory Protein gamma (SIRPG) (AA 29-364) (Active) protein (Fc Tag) (ABIN2181773) Human SIRP gamma, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Background publications Fenoglio, Galimberti, Ban, Maranian, Scalabrini, Venturelli, Piccio, De Riz, Yeo, Goris, Gray, Bresolin, Scarpini, Compston, Sawcer: "SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis." in: Neuroscience letters, Vol. 394, Issue 2, pp. 92-6, 2006 (PubMed).

Piccio, Vermi, Boles, Fuchs, Strader, Facchetti, Cella, Colonna: "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation." in: Blood, Vol. 105, Issue 6, pp. 2421-7, 2005 (PubMed).

Ichigotani, Matsuda, Machida, Oshima, Iwamoto, Yamaki, Hayakawa, Hamaguchi: "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family." in: Journal of human genetics, Vol. 45, Issue 6, pp. 378-82, 2001 (PubMed).