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  • 产品名称：EphrinA3(EFNA3)(AA23-213)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
EphrinA3(EFNA3)(AA23-213)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Ephrin-A3 (Ephrin A3) is also known as EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, EFL2, EPLG3 and LERK3,which comprises the largest subfamily of receptor protein-tyrosine kinases (RTKs), and has been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Ephrin A3 is cell surface GPI-bound ligand for Eph receptors and belongs to the family of receptor tyrosine kinases. Ephrin can bind promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Molecular Weight 48 kDa
UniProt P52797
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Ephrin A3 (EFNA3) (AA 23-213) (Active) protein (Fc Tag) (ABIN2181027) Human Ephrin-A3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained...
Background publications Kozlosky, Maraskovsky, McGrew, VandenBos, Teepe, Lyman, Srinivasan, Fletcher, Gayle, Cerretti: "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins." in: Oncogene, Vol. 10, Issue 2, pp. 299-306, 1995 (PubMed).

Davis, Gale, Aldrich, Maisonpierre, Lhotak, Pawson, Goldfarb, Yancopoulos: "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity." in: Science (New York, N.Y.), Vol. 266, Issue 5186, pp. 816-9, 1994 (PubMed).