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  • 产品名称：Follistatin-Like1(FSTL1)(AA21-308)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Follistatin-Like1(FSTL1)(AA21-308)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 32.7 kDa. The protein migrates as 35-50 kDa under reducing (R) condition (SDS-PAGE) due to differtent glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. When rhFSTL1 / FRP is coated at 2 μg/mL (100 μL/well), the concentration of rhBMP-4 that produces 50% of the optimal binding response is found to be approximately 15-70 ng/mL.
Background Follistatin-related protein 1 (FSTL1) is also known as Follistatin-like protein 1 (FRP). FSTL1 is a secreted protein that contains two EF-hand domains, one follistatin-like domain, one Kazal-like domain and one VWFC domain. FSTL1 is overexpressed in synovial tissues from rheumatoid arthritis. Follistatin-like protein 1 / FSTL1 may modulate the action of some growth factors on cell proliferation and differentiation. FSTL1 binds heparin.
Molecular Weight 32.7 kDa
UniProt Q12841
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Follistatin-Like 1 (FSTL1) (AA 21-308) (Active) protein (His tag) (ABIN2181121) Follistatin-Like 1 (FSTL1) (AA 21-308) (Active) protein (His tag)
Background publications Ehara, Sakurai, Tsuchiya, Nakano, Tanaka, Yamaguchi, Tokunaga: "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility." in: Clinical and experimental rheumatology, Vol. 22, Issue 6, pp. 707-12, 2005 (PubMed).

Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).