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  • 产品名称：PlasminogenActivator,UrokinaseReceptor(PLAUR)(AA23-303)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
PlasminogenActivator,UrokinaseReceptor(PLAUR)(AA23-303)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 32.1 kDa. The protein migrates as 44-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human uPAR at 5 μg/mL ( 100 μL/well ) can bind biotinylated human UPA with a linear ranger of 25 - 500 ng/mL.
Background Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.
Molecular Weight 32.1 kDa
UniProt Q03405
Pathways Inositol Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Plasminogen Activator, Urokinase Receptor (PLAUR) (AA 23-303) (Active) protein (His tag) (ABIN2181889) Human uPAR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Royer-Zemmour, Ponsole-Lenfant, Gara, Roll, Lévêque, Massacrier, Ferracci, Cillario, Robaglia-Schlupp, Vincentelli, Cau, Szepetowski: "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR." in: Human molecular genetics, Vol. 17, Issue 23, pp. 3617-30, 2008 (PubMed).

Huai, Mazar, Kuo, Parry, Shaw, Callahan, Li, Yuan, Bian, Chen, Furie, Furie, Cines, Huang: "Structure of human urokinase plasminogen activator in complex with its receptor." in: Science (New York, N.Y.), Vol. 311, Issue 5761, pp. 656-9, 2006 (PubMed).

List, Jensen, Bugge, Lund, Ploug, Danø, Behrendt: "Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice." in: Biochemistry, Vol. 39, Issue 3, pp. 508-15, 2000 (PubMed).

Behrendt, Jensen, Engelholm, Mørtz, Mann, Danø: "A urokinase receptor-associated protein with specific collagen binding properties." in: The Journal of biological chemistry, Vol. 275, Issue 3, pp. 1993-2002, 2000 (PubMed).