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  • 产品名称：SialicAcidBindingIg-LikeLectin5(SIGLEC5)(AA17-434)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
SialicAcidBindingIg-LikeLectin5(SIGLEC5)(AA17-434)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73 kDa. The protein migrates as 90-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Sialic acid-binding Ig-like lectin 5 (SIGLEC5) is also known as CD33 antigen-like 2 (CD33L2), Obesity-binding protein 2 (OB-BP2), CD antigen CD170, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 / CD170 is expressed by monocytic / myeloid lineage cells. SIGLEC-5 / CD33-L2 binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Molecular Weight 73 kDa
UniProt O15389
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 17-434) (Active) protein (Fc Tag) (ABIN2181761) Human Siglec-5, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Zhuravleva, Trandem, Sun: "Structural implications of Siglec-5-mediated sialoglycan recognition." in: Journal of molecular biology, Vol. 375, Issue 2, pp. 437-47, 2007 (PubMed).

Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: "OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22729-38, 1999 (PubMed).

Cornish, Freeman, Forbes, Ni, Zhang, Cepeda, Gentz, Augustus, Carter, Crocker: "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33." in: Blood, Vol. 92, Issue 6, pp. 2123-32, 1998 (PubMed).