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  • 产品名称：Roundabout,AxonGuidanceReceptor,Homolog4(Drosophila)(ROBO4)(AA28-469)(Active)pr

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  • 产品厂商：ACROBiosystems
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简单介绍：
Roundabout,AxonGuidanceReceptor,Homolog4(Drosophila)(ROBO4)(AA28-469)(Active)protein(StrepTag,Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.5 kDa. The protein migrates as 55-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Roundabout homolog 4 (ROBO4) is also known as Magic roundabout (MRB) and ECSM4, which belongs to the immunoglobulin superfamily or ROBO family. ROBO4 contains 2 fibronectin type-III domains and 2 Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is specifically expressed in endothelial cells and is also expressed at sites of angiogenesis in different tumor types. ROBO4 / MRB is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO-4 may mediate the inhibition of primary endothelial cell migration by Slit proteins.
Molecular Weight 48.5 kDa
UniProt Q8WZ75
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) (AA 28-469) (Active) protein (Strep Tag,His tag) (ABIN2181695) Human ROBO4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Huminiecki, Gorn, Suchting, Poulsom, Bicknell: "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis." in: Genomics, Vol. 79, Issue 4, pp. 547-52, 2002 (PubMed).

Hubbard, Barker, Birney, Cameron, Chen, Clark, Cox, Cuff, Curwen, Down, Durbin, Eyras, Gilbert, Hammond, Huminiecki, Kasprzyk, Lehvaslaiho, Lijnzaad, Melsopp, Mongin, Pettett, Pocock, Potter, Rust et al.: "The Ensembl genome database project. ..." in: Nucleic acids research, Vol. 30, Issue 1, pp. 38-41, 2001 (PubMed).