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  • 产品名称：CarcinoembryonicAntigen-RelatedCellAdhesionMolecule1(BiliaryGlycoprotein)(CEACA

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  • 产品厂商：ACROBiosystems
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简单介绍：
CarcinoembryonicAntigen-RelatedCellAdhesionMolecule1(BiliaryGlycoprotein)(CEACAM1)(AA35-428)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.2 kDa. The protein migrates as 60-130 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is also known as Biliary glycoprotein 1 (BGP1), CD66a, which belongs to the immunoglobulin superfamily or CEA family. CEACAM1 /CD66a contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CEACAM1 /CD66a was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 / BGP-1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
Molecular Weight 44.2 kDa
UniProt P13688
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) (CEACAM1) (AA 35-428) (Active) protein (His tag) (ABIN2180867) Human CEACAM-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained...
Background publications Chen, Jiang, Sun, Han, Wang, Ye, Wang, Zou: "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." in: Journal of proteome research, Vol. 8, Issue 2, pp. 651-61, 2009 (PubMed).

Watt, Fawcett, Murdoch, Teixeira, Gschmeissner, Hajibagheri, Simmons: "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant." in: Blood, Vol. 84, Issue 1, pp. 200-10, 1994 (PubMed).

Kuroki, Arakawa, Matsuo, Oikawa, Nakazato, Matsuoka: "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library." in: Biochemical and biophysical research communications, Vol. 176, Issue 2, pp. 578-85, 1991 (PubMed).