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  • 产品名称：Thioredoxin2(TXN2)(AA60-166)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Thioredoxin2(TXN2)(AA60-166)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Purity >97 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Thioredoxin-2 (TXN2),a member of the thioredoxin family,is also known as mitochondrial (MTRX or Mt-Trx) and TRX2.TXN2 have two important domains: Redox-active center and Transit peptide. TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Also, TXN2 could be involved in the resistance to anti-tumor agents. TNX2 possesses a dithiol-reducing activity as well.
Molecular Weight 12.8 kDa
UniProt Q99757
Pathways Cell RedoxHomeostasis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Thioredoxin 2 (TXN2) (AA 60-166) (Active) protein (His tag) (ABIN2181878) Human Thioredoxin-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was st...
Background publications Smeets, Evrard, Landtmeters, Marchand, Knoops, Declercq: "Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2." in: Protein science : a publication of the Protein Society, Vol. 14, Issue 10, pp. 2610-21, 2005 (PubMed).

Cunnea, Miranda-Vizuete, Bertoli, Simmen, Damdimopoulos, Hermann, Leinonen, Huikko, Gustafsson, Sitia, Spyrou: "ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress." in: The Journal of biological chemistry, Vol. 278, Issue 2, pp. 1059-66, 2003 (PubMed).

Damdimopoulos, Miranda-Vizuete, Pelto-Huikko, Gustafsson, Spyrou: "Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33249-57, 2002 (PubMed).

Chen, Cai, Murphy, Jones: "Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33242-8, 2002 (PubMed).