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  • 产品名称：Shwachman-Bodian-DiamondSyndrome(SBDS)(AA2-250)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Shwachman-Bodian-DiamondSyndrome(SBDS)(AA2-250)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).
Purity >98 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Shwachman-Bodian-Diamond syndrome protein (SBDS),a member of the SDO1/SBDS family, is also known as ribosome maturation protein SBDS. SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, SBDS triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby SBDS can activate ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is also required for normal levels of protein synthesis. Furthermore, SBDS may play a role in cellular stress resistance.,response to DNA damage and cell proliferation.
Molecular Weight 30 kDa
UniProt Q9Y3A5
Pathways Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Shwachman-Bodian-Diamond Syndrome (SBDS) (AA 2-250) (Active) protein (His tag) (ABIN2181723) Human SBDS, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Hesling, Oliveira, Castilho, Zanchin: "The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels." in: Experimental cell research, Vol. 313, Issue 20, pp. 4180-95, 2007 (PubMed).

Austin, Leary, Shimamura: "The Shwachman-Diamond SBDS protein localizes to the nucleolus." in: Blood, Vol. 106, Issue 4, pp. 1253-8, 2005 (PubMed).

Boocock, Morrison, Popovic, Richards, Ellis, Durie, Rommens: "Mutations in SBDS are associated with Shwachman-Diamond syndrome." in: Nature genetics, Vol. 33, Issue 1, pp. 97-101, 2003 (PubMed).