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  • 产品名称：S100CalciumBindingProteinA14(S100A14)(AA1-110)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
S100CalciumBindingProteinA14(S100A14)(AA1-110)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.5 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Protein S100-A14 (S100A14) is also known as S100 calcium-binding protein A14 (S114),which belongs to the S-100 family, containing one EF-hand domain.S100A14 is a homodimer can interact with AGER. S100A14 can modulate P53/TP53 protein levels, and play a role in the regulation of cell survival and apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).S100A14 also plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53.
Molecular Weight 12.5 kDa
UniProt Q9HCY8
Pathways Activation of Innate immune Response
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for S100 Calcium Binding Protein A14 (S100A14) (AA 1-110) (Active) protein (His tag) (ABIN2181715) Human S100A14, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Chen, Yuan, Zhang, Luo, Ding, Ma, Yang, Tian, Tong, Zhan, Liu: "Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation." in: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17109-19, 2012 (PubMed).

Sapkota, Costea, Blø, Bruland, Lorens, Vasstrand, Ibrahim: "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest." in: Oral oncology, Vol. 48, Issue 3, pp. 219-25, 2012 (PubMed).