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  • 产品名称：Chemokine(C-CMotif)Ligand6(CCL6)(AA22-116)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Chemokine(C-CMotif)Ligand6(CCL6)(AA22-116)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.4 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR1.The ED50 for this effect is typically 0.01-0.15 μg/mL.
Background Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. CCL6 has only been identified in rodents, A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where it is strongly induced upon GM-CSF (Cat. # GMF-H4214) stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 (Cat. # IL4-H4218) in mouse macrophages and by cytokine IL-13 (Cat. # IL3-H4210) in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
Molecular Weight 11.4 kDa
UniProt P27784
Research Area Innate Immunity, Chemokines, Immunology
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Chemokine (C-C Motif) Ligand 6 (CCL6) (AA 22-116) (Active) protein (His tag) (ABIN2180683) Mouse CCL6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Berger, Kozak, Gabriel, Prystowsky: "The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines." in: DNA and cell biology, Vol. 12, Issue 9, pp. 839-47, 1993 (PubMed).

Orlofsky, Berger, Prystowsky: "Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes." in: Cell regulation, Vol. 2, Issue 5, pp. 403-12, 1991 (PubMed).