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  • 产品名称：CD19Molecule(CD19)(AA20-292)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD19Molecule(CD19)(AA20-292)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.7 kDa. The protein migrates as 66-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by reduced SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.
Molecular Weight 56.7kDa
UniProt F7F486
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD19 Molecule (CD19) (AA 20-292) (Active) protein (Fc Tag) (ABIN2180710) Rhesus macaque CD19 (20-292), Fc Tag on SDS-PAGE under reducing (R) condition. The ge...
Background publications Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and ***** testis." in: Genes & development, Vol. 6, Issue 9, pp. 1589-607, 1992 (PubMed).

Kozmik, Wang, Dörfler, Adams, Busslinger: "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP." in: Molecular and cellular biology, Vol. 12, Issue 6, pp. 2662-72, 1992 (PubMed).

Stamenkovic, Seed: "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail." in: The Journal of experimental medicine, Vol. 168, Issue 3, pp. 1205-10, 1988 (PubMed).