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  • 产品名称：VascularEndothelialGrowthFactorB(VEGFB)(AA22-207)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
VascularEndothelialGrowthFactorB(VEGFB)(AA22-207)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 15-18 kDa and 33-35 kDa on a SDS-PAGE gel under reducing (R) condition.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Molecular Weight 20.2 kDa
NCBI Accession NP_003368
UniProt P49765
Pathways RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Restrictions For Research Use only
Format Lyophilized
Reconstitution For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) (Active) protein (His tag) (ABIN2181909) Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) (Active) protein (His tag)
Background publications Iyer, Scotney, Nash, Ravi Acharya: "Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding." in: Journal of molecular biology, Vol. 359, Issue 1, pp. 76-85, 2006 (PubMed).

Olofsson, Pajusola, Kaipainen, von Euler, Joukov, Saksela, Orpana, Pettersson, Alitalo, Eriksson: "Vascular endothelial growth factor B, a novel growth factor for endothelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 6, pp. 2576-81, 1996 (PubMed).