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  • 产品名称：Olfactomedin4(OLFM4)(AA21-510)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Olfactomedin4(OLFM4)(AA21-510)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 56 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Olfactomedin-4 (OLM-4) is also known as OLFM4, antiapoptotic protein GW112, G-CSF-stimulated clone 1 protein (hGC-1), hOLfD, is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. OLFM4 may promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. OLFM4 may play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. The human OLFM4 is also thought to be a useful marker for early myeloid development.
Molecular Weight 56 kDa
NCBI Accession NP_006409
UniProt Q6UX06
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Olfactomedin 4 (OLFM4) (AA 21-510) (Active) protein (His tag) (ABIN2181562) Human Olfactomedin-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was s...
Background publications Liu, Lee, Liu, Wang, Rodgers: "Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis." in: Blood, Vol. 116, Issue 23, pp. 4938-47, 2010 (PubMed).

Kobayashi, Koshida, Moriai, Tsuji, Watanabe: "Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells." in: Cancer science, Vol. 98, Issue 3, pp. 334-40, 2007 (PubMed).

Liu, Chen, Zhu, Rodgers: "The glycoprotein hGC-1 binds to cadherin and lectins." in: Experimental cell research, Vol. 312, Issue 10, pp. 1785-97, 2006 (PubMed).