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  • 产品名称：BandTLymphocyteAssociated(BTLA)(AA31-134)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
BandTLymphocyteAssociated(BTLA)(AA31-134)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 38.7 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.
Molecular Weight 38.7 kDa
NCBI Accession NP_001078826
UniProt Q7Z6A9
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for B and T Lymphocyte Associated (BTLA) (AA 31-134) (Active) protein (Fc Tag) (ABIN2180655) Human BTLA (31-134), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was sta...
Binding Studies (Bind) image for B and T Lymphocyte Associated (BTLA) (AA 31-134) (Active) protein (Fc Tag) (ABIN2180655) Immobilized Human HVEM, His Tag (Cat # HVM-H52E9) at 5 μg/mL (100 μL/well) can bind H...
Background publications Sedy, Gavrieli, Potter, Hurchla, Lindsley, Hildner, Scheu, Pfeffer, Ware, Murphy, Murphy: "B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator." in: Nature immunology, Vol. 6, Issue 1, pp. 90-8, 2004 (PubMed).

Watanabe, Gavrieli, Sedy, Yang, Fallarino, Loftin, Hurchla, Zimmerman, Sim, Zang, Murphy, Russell, Allison, Murphy: "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1." in: Nature immunology, Vol. 4, Issue 7, pp. 670-9, 2003 (PubMed).

Gavrieli, Watanabe, Loftin, Murphy, Murphy: "Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2." in: Biochemical and biophysical research communications, Vol. 312, Issue 4, pp. 1236-43, 2003 (PubMed).