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  • 产品名称：LeukocyteImmunoglobulin-LikeReceptor,SubfamilyA(WithoutTMDomain),Member3(LILRA3

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  • 产品厂商：ACROBiosystems
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简单介绍：
LeukocyteImmunoglobulin-LikeReceptor,SubfamilyA(WithoutTMDomain),Member3(LILRA3)(AA24-439)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 71.7 kDa. The protein migrates as 102 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) is also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain, which contains 4 Ig-like C2-type (immunoglobulin-like) domains. LILRA3 acts as soluble receptor for class I MHC antigens. At the same time,LILRA3 can bind both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Also,LILRA3 can bind with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Molecular Weight 71.7 kDa
UniProt Q8N6C8
Research Area Immunology
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 3 (LILRA3) (AA 24-439) (Active) protein (Fc Tag) (ABIN2181468) Human LILRA3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Borges, Hsu, Fanger, Kubin, Cosman: "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 11, pp. 5192-6, 1998 (PubMed).

Arm, Nwankwo, Austen: "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 5, pp. 2342-9, 1997 (PubMed).