产品详情
查看大图

  • 产品名称：Interleukin5Receptor,alpha(IL5RA)(AA21-335)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Interleukin5Receptor,alpha(IL5RA)(AA21-335)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.7 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >85 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.
Molecular Weight 37.7 kDa
NCBI Accession NP_000555
UniProt Q01344
Pathways JAK-STAT Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 5 Receptor, alpha (IL5RA) (AA 21-335) (Active) protein (His tag) (ABIN2181392) Human IL-5 R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was sta...
Background publications Patino, Kotzsch, Saremba, Nickel, Schmitz, Sebald, Mueller: "Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5R?." in: Structure (London, England : 1993), Vol. 19, Issue 12, pp. 1864-75, 2011 (PubMed).

Tavernier, Devos, Cornelis, Tuypens, Van der Heyden, Fiers, Plaetinck: "A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF." in: Cell, Vol. 66, Issue 6, pp. 1175-84, 1991 (PubMed).

Van der Heyden, Devos, Plaetinck, Fache, Fiers, Tavernier: "Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies. Relationship to the murine IL-3 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 10, pp. 3413-8, 1991 (PubMed).