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  • 产品名称：serpinPeptidaseInhibitor,CladeH(HeatShockProtein47),Member1,(CollagenBindingPro

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  • 产品厂商：ACROBiosystems
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简单介绍：
serpinPeptidaseInhibitor,CladeH(HeatShockProtein47),Member1,(CollagenBindingProtein1)(SERPINH1)(AA19-418)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.3 kDa. The protein migrates as 47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Serpin H1 is also known as SERPINH1, 47 kDa heat shock protein (HSP47), Collagen-binding protein (Colligin), Arsenic-transactivated protein 3 (AsTP3), which belongs to the serpin family. SERPINH1 binds specifically to collagen. SERPINH1 / HSP47 could be involved as a chaperone in the biosynthetic pathway of collagen.
Molecular Weight 45.3 kDa
NCBI Accession NP_001226
UniProt P50454
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) (AA 19-418) (Active) protein (His tag) (ABIN2181754) Human Serpin H1, His Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Background publications Christiansen, Schwarze, Pyott, AlSwaid, Al Balwi, Alrasheed, Pepin, Weis, Eyre, Byers: "Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta." in: American journal of human genetics, Vol. 86, Issue 3, pp. 389-98, 2010 (PubMed).

Hattori, Takahash, Yutani, Fujisawa, Nakanishi, Takigawa: "Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47." in: Journal of bone and mineral metabolism, Vol. 18, Issue 6, pp. 328-34, 2001 (PubMed).