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  • 产品名称：ScavengerReceptorClassB,Member1(SCARB1)(AA33-443)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ScavengerReceptorClassB,Member1(SCARB1)(AA33-443)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.6 kDa. As a result of glycosylation, the protein migrates as 110-115 kDa under reducing (R) condition, and 220-230 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind recombinant Human ApoAI (Catalog # AP1-H5225) in a functional ELISA.
Background Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.
Molecular Weight 72.6 kDa
NCBI Accession NP_005496
UniProt Q8WTV0
Pathways Cellular Response to Molecule of Bacterial Origin, Hepatitis C
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Scavenger Receptor Class B, Member 1 (SCARB1) (AA 33-443) (Active) protein (Fc Tag) (ABIN2181726) Human SCARB1, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. ...
Background publications Scarselli, Ansuini, Cerino, Roccasecca, Acali, Filocamo, Traboni, Nicosia, Cortese, Vitelli: "The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus." in: The EMBO journal, Vol. 21, Issue 19, pp. 5017-25, 2002 (PubMed).