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  • 产品名称：Neuroligin3(NLGN3)(AA38-689)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Neuroligin3(NLGN3)(AA38-689)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 74.4 kDa. The protein migrates as 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Neuroligin 3 (NLGN3),a single-pass type I membrane protein ,is also known as gliotactin homolog and KIAA1480, which belongs to the type-B carboxylesterase/lipase family. As the cell surface protein,NLGN3 is involved in cell-cell-interactions via its interactions with neurexin family members. NLGN3 also plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. NLGN3 probably can promote the initial formation of synapses, but is not essential for this. Furthermore,NLGN3 may also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
Molecular Weight 74.4 kDa
UniProt Q9NZ94
Research Area Neurology, Glia marker
Pathways Synaptic Membrane
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Neuroligin 3 (NLGN3) (AA 38-689) (Active) protein (His tag) (ABIN2181537) Human Neuroligin 3, His Tag on SDS-PAGE under reducing (R) condition. The gel was sta...
Background publications Suckow, Comoletti, Waldrop, Mosedale, Egodage, Taylor, Chessler: "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion." in: Endocrinology, Vol. 149, Issue 12, pp. 6006-17, 2008 (PubMed).

Graf, Zhang, Jin, Linhoff, Craig: "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins." in: Cell, Vol. 119, Issue 7, pp. 1013-26, 2004 (PubMed).